Traditionally Nuclear Research and Development (R&D) result has been big influence on other industries and societies and it requires large scale investments and study period. So it is essential to apply Quality Assurance (QA) for systematic R&D management. This paper investigates QA System for U.S. Nuclear R&D and reviews QA elements. Based on this investigation, we applied QA requirements to Nuclear Hydrogen R&D project, and the scope of application be enlarged as R&D stage in progress. We also present QA system improvement way through consideration for Nuclear Hydrogen Project's QA application. As the need for QA in R&D is expected to increase in the future, it is necessary to prepare guidelines for R&D QA.